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Make the sauce: In a small bowl, whisk together the Greek yogurt, ketchup, pickle relish, Dijon mustard, apple cider vinegar, Worcestershire sauce, garlic powder, onion powder, paprika, and salt & pepper until smooth. Cover and refrigerate until ready to serve.
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In a bowl, combine the ground beef with the garlic powder, onion powder, paprika, salt, and pepper.
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Scoop about 1/4 cup of beef onto each taco and press a thin layer of beef mixture evenly over one side of each tortilla, spreading nearly to the edges.
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Heat a large skillet over medium heat and lightly coat with avocado oil. Place the tacos beef-side down first.
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Cook for 3-5 minutes until the beef develops a golden crust.
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Flip and cook another 1-2 minutes until the tortilla becomes lightly crisp and the beef is cooked through.
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Remove from the skillet and top with the cheddar cheese (if using) while still hot.
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Finish with the toppings: lettuce, tomatoes, onions, pickles, a generous drizzle of special sauce, and a sprinkle of sesame seeds if desired.
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Store leftover smash burger tacos and toppings separately in airtight containers in the refrigerator for up to 3 days. Keeping the toppings separate helps the tortillas stay crisp.
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To reheat, warm the tacos in a skillet or air fryer for 2–4 minutes until heated through and crispy again. Add the fresh toppings and sauce after reheating for the best flavor and texture.